Product Name :
TRIM72 Mouse Monoclonal Antibody [A1D4]
Predicted band size :
53 kDa
Observed band size :
53 kDa
Synonyms:
LOC493829 antibody Mg53 antibody Mitsugumin-53 antibody TRI72_HUMAN antibody trim72 antibody Tripartite motif containing 72 antibody Tripartite motif containing protein 72 antibody Tripartite motif-containing protein 72 antibody
Function :
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites.D-Ala-D-Ala Price Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca2+-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein with Human TRIM72 aa 50-150 / 477.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P, FC
Coupling :
unconjugated
Clone number:
A1D4
RRID:
AB_3068890
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃ after thawing.tert-Butyl hept-6-ynoate structure Aliquot store at -20℃.PMID:33395714 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 53 kDa
Positive control :
HCT 116 cell lysate, mouse skeletal muscle tissue lysate, mouse heart tissue lysate, rat heart tissue lysate, rat skeletal muscle tissue lysate, rat skeletal muscle tissue, human pancreas tissue, A549.