Product Name :
UBN-1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
Ubinuclein 1 antibody Ubinuclein antibody Ubiquitously expressed nuclear protein antibody VT antibody VT4 antibody
Function :
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. Belongs to the ubinuclein family. subcellular location:Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis.5-Chloro-1,3-benzoxazol-7-amine supplier When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.tert-Butyl propiolate custom synthesis subunit:Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.PMID:33387266 3 and UBN1. Interacts with Epstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain); the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3. tissue specificity:Ubiquitous. Also expressed in numerous tumors and cancer cell lines.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
The antiserum was produced against synthesized peptide derived from human Ubinuclein. AA range:161-210
Species reactivity:
Human, Mouse
Verify application:
WB, IHC-P, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Positive control :
Cervix carcinoma,Epithelium,Placenta,