Product Name :
p47-phox Mouse Monoclonal Antibody [A6B11]
Predicted band size :
45 kDa
Observed band size :
45 kDa
Synonyms:
47 kDa autosomal chronic granulomatous disease protein antibody 47 kDa neutrophil oxidase factor antibody NADPH oxidase organizer 2 antibody NCF 47K antibody NCF-1 antibody NCF-47K antibody Ncf1 antibody NCF1_HUMAN antibody Neutrophil cytosol factor 1 antibody Neutrophil cytosolic factor 1 antibody 展开
Function :
The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47phox and p67-phox. The cytosolic proteins p47phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47phox, suggesting that p47phox may faciliate the transport of p67-phox to the membrane.154065-33-5 Chemical name
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein within human p47-phox aa 51-250.Buy(S)-(-)-3-Butyn-2-ol
Species reactivity:
Human, Mouse
Verify application:
WB, IF-Cell, IHC-P
Coupling :
unconjugated
Clone number:
A6B11
RRID:
AB_3071666
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33441260 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG1
Purification method :
Protein G affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 45 kDa
Positive control :
Ramos cell lysate, Raji cell lysate, Daudi cell lysate, HL-60 cell lysate, Hela, NIH/3T3, human lung tissue, human spleen tissue.