Product Name :
3,5-Diiodo-L-thyronine (CAS 1041-01-6)
Synonym :
O-(4-Hydroxyphenyl)-3,5-diiodo-L-tyrosine; 3-[4-(p-Hydroxyphenoxy)-3,5-diiodophenyl]-L-alanine; L-T2
Application :
3,5-Diiodo-L-thyronine is an iodinated thyronine hormone that regulates activity
CAS:
1041-01-6
Purity:
≥95%
Molecular Weight:
525.08
Formula :
C15H13I2NO4
Physical state:
Solid
solubility :
Soluble in methanol (sparingly), DMSO (sparingly), Acidic Solution, water (partly), and 10 mg per one ml of 4 M Ammonium Hydroxide in Methanol.
Shipping Condition :
Store at -20° C
Melting point:
255° C
SMILES:
N[C@@H](CC1=CC(I)=C(OC2=CC=C(O)C=C2)C(I)=C1)C(O)=O
References:
:3,5-Diiodo-L-thyronine administration to hypothyroid rats rapidly enhances fatty acid oxidation rate and bioenergetic parameters in liver cells. | Cavallo, A., et al. 2013. PLoS One. 8: e52328. PMID: 233081103,5-Diiodo-l-thyronine ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats. | Shang, G., et al.205319-06-8 chemscene 2013. Biochim Biophys Acta. 1832: 674-84. PMID: 23416120Hippocampal gene expression of deiodinases 2 and 3 and effects of 3,5-diiodo-L-thyronine T2 in mouse depression paradigms. | Markova, N., et al. 2013. Biomed Res Int. 2013: 565218. PMID: 243866383,5-diiodo-L-thyronine modifies the lipid droplet composition in a model of hepatosteatosis. | Grasselli, E., et al. 2014. Cell Physiol Biochem. 33: 344-56. PMID: 245259033,5-Diiodo-L-thyronine (3,5-t2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice. | Jonas, W., et al. 2015. Endocrinology. 156: 389-99. PMID: 253224653,5-diiodo-L-thyronine (t2) in dietary supplements: what are the physiological effects? | Hernandez, A. 2015. Endocrinology. 156: 5-7.84476-99-3 Computational Chemistry Data PMID: 25526549Proteomic approaches for the study of tissue specific effects of 3,5,3′-triiodo-L-thyronine and 3,5-diiodo-L-thyronine in conditions of altered energy metabolism. | Silvestri, E., et al. 2014. Front Physiol. 5: 491. PMID: 255660893,5-Diiodo-L-thyronine activates brown adipose tissue thermogenesis in hypothyroid rats. | Lombardi, A., et al. 2015. PLoS One. 10: e0116498. PMID: 256583243,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats. | Vatner, DF., et al. 2015. PLoS One.PMID:33480434 10: e0140837. PMID: 264854333,5-diiodo-L-thyronine: A Possible Pharmacological Agent? | Coppola, M., et al. 2016. Curr Drug Deliv. 13: 330-8. PMID: 26593437Acute administration of 3,5-diiodo-L-thyronine to hypothyroid rats stimulates bioenergetic parameters in liver mitochondria. | Cavallo, A., et al. 2016. J Bioenerg Biomembr. 48: 521-529. PMID: 278540293,5,3′-Triiodo-L-Thyronine- and 3,5-Diiodo-L-Thyronine- Affected Metabolic Pathways in Liver of LDL Receptor Deficient Mice. | Moreno, M., et al. 2016. Front Physiol. 7: 545. PMID: 27909409Direct and rapid effects of 3,5-diiodo-L-thyronine (T2). | Moreno, M., et al. 2017. Mol Cell Endocrinol. 458: 121-126. PMID: 28192176Both 3,5-diiodo-L-thyronine (T2) and T3 modulate glucose-induced insulin secretion. | Fallahi, P., et al. 2017. J Biol Regul Homeost Agents. 31: 503-508. PMID: 28685559Both 3,5-Diiodo-L-Thyronine and 3,5,3′-Triiodo-L-Thyronine Prevent Short-term Hepatic Lipid Accumulation via Distinct Mechanisms in Rats Being Fed a High-Fat Diet. | Senese, R., et al. 2017. Front Physiol. 8: 706. PMID: 28959215